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Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.
Schnute, Mark E; Wennerstål, Mattias; Alley, Jennifer; Bengtsson, Martin; Blinn, James R; Bolten, Charles W; Braden, Timothy; Bonn, Tomas; Carlsson, Bo; Caspers, Nicole; Chen, Ming; Choi, Chulho; Collis, Leon P; Crouse, Kimberly; Färnegårdh, Mathias; Fennell, Kimberly F; Fish, Susan; Flick, Andrew C; Goos-Nilsson, Annika; Gullberg, Hjalmar; Harris, Peter K; Heasley, Steven E; Hegen, Martin; Hromockyj, Alexander E; Hu, Xiao; Husman, Bolette; Janosik, Tomasz; Jones, Peter; Kaila, Neelu; Kallin, Elisabet; Kauppi, Björn; Kiefer, James R; Knafels, John; Koehler, Konrad; Kruger, Lars; Kurumbail, Ravi G; Kyne, Robert E; Li, Wei; Löfstedt, Joakim; Long, Scott A; Menard, Carol A; Mente, Scot; Messing, Dean; Meyers, Marvin J; Napierata, Lee; Nöteberg, Daniel; Nuhant, Philippe; Pelc, Matthew J; Prinsen, Michael J; Rhönnstad, Patrik.
Affiliation
  • Wennerstål M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Bengtsson M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Bonn T; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Carlsson B; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Caspers N; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Chen M; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Choi C; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Färnegårdh M; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Fennell KF; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Flick AC; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Goos-Nilsson A; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Gullberg H; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Heasley SE; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Husman B; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Janosik T; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Kallin E; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Kauppi B; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Knafels J; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Koehler K; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Kruger L; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Kurumbail RG; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Kyne RE; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Löfstedt J; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Menard CA; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Nöteberg D; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
  • Nuhant P; Medicine Design , Pfizer Inc. , Groton , Connecticut 06340 , United States.
  • Rhönnstad P; Karo Bio AB (now Karo Pharma AB) , 111 48 Stockholm , Sweden.
J Med Chem ; 61(23): 10415-10439, 2018 12 13.
Article in En | MEDLINE | ID: mdl-30130103
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Drug Design / Drug Inverse Agonism / Nuclear Receptor Subfamily 1, Group F, Member 3 Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Drug Design / Drug Inverse Agonism / Nuclear Receptor Subfamily 1, Group F, Member 3 Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2018 Type: Article