Recombinant human arginase induces apoptosis through oxidative stress and cell cycle arrest in small cell lung cancer.

Xu, Shi; Lam, Sze-Kwan; Cheng, Paul Ning-Man; Ho, James Chung-Man

Xu, Shi; Lam, Sze-Kwan; Cheng, Paul Ning-Man; Ho, James Chung-Man.

Affiliation

Xu S; Division of Respiratory Medicine, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Lam SK; Division of Respiratory Medicine, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.
Cheng PN; Bio-Cancer Treatment International, Tai Po, Hong Kong, China.
Ho JC; Division of Respiratory Medicine, Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, China.

Cancer Sci ; 109(11): 3471-3482, 2018 Nov.

Article in En | MEDLINE | ID: mdl-30155941

Subject(s)

Antineoplastic Agents/administration & dosage; Arginase/administration & dosage; Lung Neoplasms/drug therapy; Recombinant Proteins/administration & dosage; Small Cell Lung Carcinoma/drug therapy; Animals; Antineoplastic Agents/pharmacology; Arginase/pharmacology; Arginine/metabolism; Cell Cycle/drug effects; Cell Line, Tumor; Cell Proliferation/drug effects; Cell Survival/drug effects; Gene Expression Regulation, Neoplastic/drug effects; Humans; Lung Neoplasms/metabolism; Mice; Oxidative Stress; Recombinant Proteins/pharmacology; Small Cell Lung Carcinoma/metabolism; Xenograft Model Antitumor Assays

Key words

BCT-100; G1 cell cycle arrest; apoptosis; oxidative stress; small cell lung cancer

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arginase / Recombinant Proteins / Small Cell Lung Carcinoma / Lung Neoplasms / Antineoplastic Agents Limits: Animals / Humans Language: En Journal: Cancer Sci Year: 2018 Type: Article Affiliation country: China

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