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A cancer-associated polymorphism in ESCRT-III disrupts the abscission checkpoint and promotes genome instability.
Sadler, Jessica B A; Wenzel, Dawn M; Strohacker, Lauren K; Guindo-Martínez, Marta; Alam, Steven L; Mercader, Josep M; Torrents, David; Ullman, Katharine S; Sundquist, Wesley I; Martin-Serrano, Juan.
Affiliation
  • Sadler JBA; Department of Infectious Diseases, Faculty of Life Sciences and Medicine, King's College London, SE1 9RT London, United Kingdom.
  • Wenzel DM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.
  • Strohacker LK; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.
  • Guindo-Martínez M; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112.
  • Alam SL; Joint Barcelona Supercomputing Center-Centre for Genomic Regulation-Institute for Research in Biomedicine Research Program in Computational Biology, Barcelona Supercomputing Center, 08034 Barcelona, Spain.
  • Mercader JM; Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84112.
  • Torrents D; Joint Barcelona Supercomputing Center-Centre for Genomic Regulation-Institute for Research in Biomedicine Research Program in Computational Biology, Barcelona Supercomputing Center, 08034 Barcelona, Spain.
  • Ullman KS; Program in Metabolism, Broad Institute of Harvard and MIT, Cambridge, MA 02142.
  • Sundquist WI; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142.
  • Martin-Serrano J; Diabetes Unit, Massachusetts General Hospital, Boston, MA 02114.
Proc Natl Acad Sci U S A ; 115(38): E8900-E8908, 2018 09 18.
Article in En | MEDLINE | ID: mdl-30181294
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Genomic Instability / Endosomal Sorting Complexes Required for Transport / Cell Cycle Checkpoints / Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: United kingdom
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Predisposition to Disease / Genomic Instability / Endosomal Sorting Complexes Required for Transport / Cell Cycle Checkpoints / Neoplasms Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2018 Type: Article Affiliation country: United kingdom