Human Alzheimer's disease gene expression signatures and immune profile in APP mouse models: a discrete transcriptomic view of Aß plaque pathology.

Rothman, Sarah M; Tanis, Keith Q; Gandhi, Pallavi; Malkov, Vladislav; Marcus, Jacob; Pearson, Michelle; Stevens, Richard; Gilliland, Jason; Ware, Christopher; Mahadomrongkul, Veeravan; O'Loughlin, Elaine; Zeballos, Gonzalo; Smith, Roger; Howell, Bonnie J; Klappenbach, Joel; Kennedy, Matthew; Mirescu, Christian

Rothman, Sarah M; Tanis, Keith Q; Gandhi, Pallavi; Malkov, Vladislav; Marcus, Jacob; Pearson, Michelle; Stevens, Richard; Gilliland, Jason; Ware, Christopher; Mahadomrongkul, Veeravan; O'Loughlin, Elaine; Zeballos, Gonzalo; Smith, Roger; Howell, Bonnie J; Klappenbach, Joel; Kennedy, Matthew; Mirescu, Christian.

Affiliation

Rothman SM; In Vivo Pharmacology, Merck & Co, Kenilworth, New Jersey, USA.
Tanis KQ; Genetics and Genomics, Merck & Co., West Point, Pennsylvania, USA.
Gandhi P; Neuroscience, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Malkov V; Genetics and Genomics, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Marcus J; Neuroscience, Merck & Co, West Point, Pennsylvania, USA.
Pearson M; Neuroscience, Merck & Co, West Point, Pennsylvania, USA.
Stevens R; Genetics and Genomics, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Gilliland J; Genetics and Genomics, Merck & Co., West Point, Pennsylvania, USA.
Ware C; Neuroscience, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Mahadomrongkul V; Neuroscience, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
O'Loughlin E; Neuroscience, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Zeballos G; Neuroscience, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Smith R; Systems Toxicology, Merck & Co., Kenilworth, New Jersey, USA.
Howell BJ; Infectious Diseases and Vaccines, Merck & Co., West Point, Kenilworth, Pennsylvania, USA.
Klappenbach J; Genetics and Genomics, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Kennedy M; Neuroscience, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA.
Mirescu C; Neuroscience, Merck & Co., Merck Research Labs, Boston, Massachusetts, USA. christian_mirescu@merck.com.

J Neuroinflammation ; 15(1): 256, 2018 Sep 06.

Article in En | MEDLINE | ID: mdl-30189875

Subject(s)

Alzheimer Disease; Amyloid beta-Peptides/metabolism; Amyloid beta-Protein Precursor/genetics; Amyloid beta-Protein Precursor/metabolism; Cerebral Cortex/metabolism; Cytokines/metabolism; Gene Expression Regulation/genetics; Age Factors; Alzheimer Disease/genetics; Alzheimer Disease/immunology; Alzheimer Disease/metabolism; Alzheimer Disease/pathology; Amyloid beta-Peptides/genetics; Animals; Calcium-Binding Proteins/metabolism; Cerebral Cortex/pathology; Correlation of Data; Disease Models, Animal; Humans; Laser Capture Microdissection; Mice; Mice, Transgenic; Microfilament Proteins/metabolism; Mutation/genetics; Plaque, Amyloid/pathology; RNA, Messenger/metabolism; Transcriptome

Key words

Alzheimer's disease; Microglia; Neuroinflammation; Plaque; Transcriptomics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cerebral Cortex / Gene Expression Regulation / Amyloid beta-Peptides / Cytokines / Amyloid beta-Protein Precursor / Alzheimer Disease Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neuroinflammation Journal subject: NEUROLOGIA Year: 2018 Type: Article Affiliation country: United States

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