Novel gene activated in rat insulinomas.
Diabetes
; 35(10): 1178-80, 1986 Oct.
Article
in En
| MEDLINE
| ID: mdl-3019805
ABSTRACT
Insulinomas can be induced in experimental animals by the combined administration of diabetogenic agents with polyadenosine diphosphate (polyADP)-ribose synthetase inhibitors. A complementary DNA (cDNA) library that was constructed from streptozocin-nicotinamide-induced rat insulinomas has been found to contain a novel gene encoding a basic protein of 145 amino acids. The gene was expressed in alloxan-nicotinamide-induced insulinomas as well as in streptozocin-nicotinamide-induced insulinomas but not in normal pancreatic islets or in regenerating islets. This indicates that the activation of the gene designated rig, i.e., rat insulinoma gene, may be a general feature of pancreatic beta-cell transformation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oncogenes
/
Pancreatic Neoplasms
/
Adenoma, Islet Cell
/
Insulinoma
Limits:
Animals
Language:
En
Journal:
Diabetes
Year:
1986
Type:
Article