Paternally inherited WT1 mutation plus uniparental disomy of 11p may be an essential mechanism for development of WT1-mutated familial Wilms tumor.

Sato, Yuya; Haruta, Masayuki; Kaneko, Yasuhiko; Nakasato, Yoshimasa; Kurosawa, Hidemitsu; Yoshihara, Shigemi

Sato, Yuya; Haruta, Masayuki; Kaneko, Yasuhiko; Nakasato, Yoshimasa; Kurosawa, Hidemitsu; Yoshihara, Shigemi.

Affiliation

Sato Y; Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Haruta M; Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan.
Kaneko Y; Department of Cancer Diagnosis, Research Institute for Clinical Oncology, Saitama Cancer Center, Ina, Saitama, Japan.
Nakasato Y; Department of Anatomic and Diagnostic Pathology, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Kurosawa H; Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.
Yoshihara S; Department of Pediatrics, Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan.

Pediatr Blood Cancer ; 66(1): e27442, 2019 01.

Article in En | MEDLINE | ID: mdl-30221469

Subject(s)

Chromosomes, Human, Pair 11/genetics; Germ-Line Mutation; Kidney Neoplasms/genetics; Paternal Inheritance; Uniparental Disomy; WT1 Proteins/genetics; Wilms Tumor/genetics; Adult; Female; Humans; Infant; Kidney Neoplasms/pathology; Male; Pedigree; Prognosis; Wilms Tumor/pathology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Chromosomes, Human, Pair 11 / Germ-Line Mutation / Wilms Tumor / Uniparental Disomy / WT1 Proteins / Paternal Inheritance / Kidney Neoplasms Type of study: Prognostic_studies Limits: Adult / Female / Humans / Infant / Male Language: En Journal: Pediatr Blood Cancer Journal subject: HEMATOLOGIA / NEOPLASIAS / PEDIATRIA Year: 2019 Type: Article Affiliation country: Japan

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