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Genome-wide association studies and CRISPR/Cas9-mediated gene editing identify regulatory variants influencing eyebrow thickness in humans.
Wu, Sijie; Zhang, Manfei; Yang, Xinzhou; Peng, Fuduan; Zhang, Juan; Tan, Jingze; Yang, Yajun; Wang, Lina; Hu, Yanan; Peng, Qianqian; Li, Jinxi; Liu, Yu; Guan, Yaqun; Chen, Chen; Hamer, Merel A; Nijsten, Tamar; Zeng, Changqing; Adhikari, Kaustubh; Gallo, Carla; Poletti, Giovanni; Schuler-Faccini, Lavinia; Bortolini, Maria-Cátira; Canizales-Quinteros, Samuel; Rothhammer, Francisco; Bedoya, Gabriel; González-José, Rolando; Li, Hui; Krutmann, Jean; Liu, Fan; Kayser, Manfred; Ruiz-Linares, Andres; Tang, Kun; Xu, Shuhua; Zhang, Liang; Jin, Li; Wang, Sijia.
Affiliation
  • Wu S; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Zhang M; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Yang X; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
  • Peng F; Human Phenome Institute, Fudan University, 825 Zhangheng Road, Shanghai, China.
  • Zhang J; CAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Tan J; SIBS (Institute of Health Sciences) Changzheng Hospital Joint Center for Translational Research, Institutes for Translational Research (CAS-SMMU), Shanghai, China.
  • Yang Y; Key laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Wang L; Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
  • Hu Y; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
  • Peng Q; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
  • Li J; Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China.
  • Liu Y; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Guan Y; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Chen C; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Hamer MA; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Nijsten T; CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.
  • Zeng C; Department of Biochemistry, Preclinical Medicine College, Xinjiang Medical University, Urumqi, China.
  • Adhikari K; Department of Stomatology, Chang Zheng Hospital, Second Military Medical University, Shanghai, China.
  • Gallo C; Department of Dermatology, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands.
  • Poletti G; Department of Dermatology, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands.
  • Schuler-Faccini L; Key laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Bortolini MC; Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, United Kingdom.
  • Canizales-Quinteros S; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Rothhammer F; Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru.
  • Bedoya G; Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre Brasil.
  • González-José R; Departamento de Genética, Universidade Federal do Rio Grande do Sul, Porto Alegre Brasil.
  • Li H; Unidad de Genómica de Poblaciones Aplicada a la Salud, Facultad de Química, UNAM-Instituto Nacional de Medicina Genómica, México City, México.
  • Krutmann J; Instituto de Alta Investigación, Universidad de Tarapacá, Arica, Chile.
  • Liu F; Laboratorio de Genética Molecular (GENMOL), Universidad de Antioquia, Medellín, Colombia.
  • Kayser M; Instituto Patagónico de Ciencias Sociales y Humanas, Centro Nacional Patagónico, CONICET, Puerto Madryn, Argentina.
  • Ruiz-Linares A; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
  • Tang K; IUF-Leibniz Research Institute for Environmental Medicine, Dusseldorf, Germany.
  • Xu S; Key laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  • Zhang L; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands.
  • Jin L; Department of Genetic Identification, Erasmus MC University Medical Center Rotterdam, CA Rotterdam, The Netherlands.
  • Wang S; State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
PLoS Genet ; 14(9): e1007640, 2018 09.
Article in En | MEDLINE | ID: mdl-30248107
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Eyebrows / Genetic Loci Type of study: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2018 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Eyebrows / Genetic Loci Type of study: Prognostic_studies / Risk_factors_studies / Systematic_reviews Limits: Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2018 Type: Article Affiliation country: China