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Investigating Sulfoxide-to-Sulfone Conversion as a Prodrug Strategy for a Phosphatidylinositol 4-Kinase Inhibitor in a Humanized Mouse Model of Malaria.
Gibhard, Liezl; Njoroge, Mathew; Paquet, Tanya; Brunschwig, Christel; Taylor, Dale; Lawrence, Nina; Abay, Efrem; Wittlin, Sergio; Wiesner, Lubbe; Street, Leslie J; Chibale, Kelly; Basarab, Gregory S.
Affiliation
  • Gibhard L; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
  • Njoroge M; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
  • Paquet T; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
  • Brunschwig C; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
  • Taylor D; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
  • Lawrence N; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
  • Abay E; Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory, South Africa.
  • Wittlin S; Swiss Tropical and Public Health Institute, Basel, Switzerland.
  • Wiesner L; University of Basel, Basel, Switzerland.
  • Street LJ; Department of Medicine, Division of Clinical Pharmacology, University of Cape Town, Observatory, South Africa.
  • Chibale K; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
  • Basarab GS; Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch, South Africa.
Antimicrob Agents Chemother ; 62(12)2018 12.
Article in En | MEDLINE | ID: mdl-30249687
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Sulfones / Sulfoxides / Prodrugs / Malaria, Falciparum / Parasitemia / Antimalarials Language: En Journal: Antimicrob Agents Chemother Year: 2018 Type: Article Affiliation country: South Africa
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazines / Sulfones / Sulfoxides / Prodrugs / Malaria, Falciparum / Parasitemia / Antimalarials Language: En Journal: Antimicrob Agents Chemother Year: 2018 Type: Article Affiliation country: South Africa