Epigenetic Enhancer Marks and Transcription Factor Binding Influence V&#954; Gene Rearrangement in Pre-B Cells and Pro-B Cells.

Kleiman, Eden; Loguercio, Salvatore; Feeney, Ann J

Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B Cells.

Kleiman, Eden; Loguercio, Salvatore; Feeney, Ann J.

Affiliation

Kleiman E; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States.
Loguercio S; Molecular Experimental Medicine, The Scripps Research Institute, La Jolla, CA, United States.
Feeney AJ; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, United States.

Front Immunol ; 9: 2074, 2018.

Article in En | MEDLINE | ID: mdl-30271408

Subject(s)

B-Lymphocytes/physiology; Immunoglobulin Light Chains/genetics; Precursor Cells, B-Lymphoid/physiology; Animals; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; DNA, Complementary/genetics; Epigenesis, Genetic; Gene Rearrangement, B-Lymphocyte, Light Chain; Genome; Ikaros Transcription Factor/genetics; Ikaros Transcription Factor/metabolism; Immunoglobulin Variable Region/genetics; Immunoglobulin kappa-Chains/genetics; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic/genetics; Protein Binding; Proto-Oncogene Proteins/metabolism; Trans-Activators/metabolism

Key words

Next Generation Sequencing; V(D)J recombination; enhancer; immunoglobulin; pre-B cells; pro-B cells; repertoire

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Immunoglobulin Light Chains / Precursor Cells, B-Lymphoid Type of study: Prognostic_studies Limits: Animals Language: En Journal: Front Immunol Year: 2018 Type: Article Affiliation country: United States

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