Design, Synthesis, and Cytotoxic Analysis of Novel Hederageninâ»Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis.

Fang, Kang; Zhang, Xiao-Hua; Han, Yao-Tian; Wu, Gao-Rong; Cai, De-Sheng; Xue, Nan-Nan; Guo, Wen-Bo; Yang, Yu-Qin; Chen, Meng; Zhang, Xin-Yu; Wang, Hui; Ma, Tao; Wang, Peng-Long; Lei, Hai-Min

Design, Synthesis, and Cytotoxic Analysis of Novel Hederageninâ»Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis.

Fang, Kang; Zhang, Xiao-Hua; Han, Yao-Tian; Wu, Gao-Rong; Cai, De-Sheng; Xue, Nan-Nan; Guo, Wen-Bo; Yang, Yu-Qin; Chen, Meng; Zhang, Xin-Yu; Wang, Hui; Ma, Tao; Wang, Peng-Long; Lei, Hai-Min.

Affiliation

Fang K; School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China. 18364166994@163.com.

Int J Mol Sci ; 19(10)2018 Sep 30.

Article in En | MEDLINE | ID: mdl-30274380

Subject(s)

Drug Design; Oleanolic Acid/analogs & derivatives; Pyrazines/chemical synthesis; Pyrazines/toxicity; Apoptosis/drug effects; Cell Cycle/drug effects; Cell Death; Cell Line, Tumor; Cell Shape/drug effects; Cluster Analysis; Discriminant Analysis; Humans; Inhibitory Concentration 50; Least-Squares Analysis; Oleanolic Acid/chemical synthesis; Oleanolic Acid/chemistry; Oleanolic Acid/toxicity; Principal Component Analysis; Pyrazines/chemistry; Staining and Labeling; Structure-Activity Relationship

Key words

PLS-DA; antitumor activity; apoptosis; hederagenin; pyrazine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oleanolic Acid / Pyrazines / Drug Design Type of study: Prognostic_studies Limits: Humans Language: En Journal: Int J Mol Sci Year: 2018 Type: Article Affiliation country: China

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