Ubiquitin-proteasome system and ER stress in the brain of diabetic rats.

Shruthi, Karnam; Reddy, S Sreenivasa; Chitra, P Swathi; Reddy, G Bhanuprakash

Shruthi, Karnam; Reddy, S Sreenivasa; Chitra, P Swathi; Reddy, G Bhanuprakash.

Affiliation

Shruthi K; Biochemistry Division, National Institute of Nutrition, Hyderabad, India.
Reddy SS; Biochemistry Division, National Institute of Nutrition, Hyderabad, India.
Chitra PS; Biochemistry Division, National Institute of Nutrition, Hyderabad, India.
Reddy GB; Biochemistry Division, National Institute of Nutrition, Hyderabad, India.

J Cell Biochem ; 120(4): 5962-5973, 2019 04.

Article in En | MEDLINE | ID: mdl-30317658

Subject(s)

Diabetes Mellitus, Experimental/metabolism; Endoplasmic Reticulum Stress/physiology; Proteasome Endopeptidase Complex/metabolism; Ubiquitin/metabolism; Animals; Apoptosis/drug effects; Brain/metabolism; Cell Death/drug effects; Cerebral Cortex/drug effects; Cerebral Cortex/metabolism; Diabetes Mellitus, Experimental/drug therapy; Diabetes Mellitus, Experimental/genetics; Endoplasmic Reticulum Stress/drug effects; Immunoblotting; Immunohistochemistry; In Situ Nick-End Labeling; Male; Phenylbutyrates/pharmacology; Phenylbutyrates/therapeutic use; Proteasome Endopeptidase Complex/drug effects; Rats; Rats, Sprague-Dawley; Unfolded Protein Response/drug effects

Key words

4-phenylbutyric acid (4-PBA); ER-associated protein degradation (ERAD); apoptosis; chaperone; endoplasmic reticulum (ER) stress; neurodegeneration; ubiquitin-proteasome system (UPS)

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ubiquitin / Proteasome Endopeptidase Complex / Diabetes Mellitus, Experimental / Endoplasmic Reticulum Stress Limits: Animals Language: En Journal: J Cell Biochem Year: 2019 Type: Article Affiliation country: India

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