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Structure-based redesign of docking domain interactions modulates the product spectrum of a rhabdopeptide-synthesizing NRPS.
Hacker, Carolin; Cai, Xiaofeng; Kegler, Carsten; Zhao, Lei; Weickhmann, A Katharina; Wurm, Jan Philip; Bode, Helge B; Wöhnert, Jens.
Affiliation
  • Hacker C; Institute of Molecular Biosciences and Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
  • Cai X; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
  • Kegler C; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
  • Zhao L; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
  • Weickhmann AK; Institute of Molecular Biosciences and Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
  • Wurm JP; Institute of Molecular Biosciences and Center for Biomolecular Magnetic Resonance (BMRZ), Goethe University Frankfurt, 60438, Frankfurt am Main, Germany.
  • Bode HB; Institute of Biophysics and Physical Biochemistry, University of Regensburg, 93053, Regensburg, Germany.
  • Wöhnert J; Molecular Biotechnology, Department of Biosciences, Goethe University Frankfurt, 60438, Frankfurt am Main, Germany. h.bode@bio.uni-frankfurt.de.
Nat Commun ; 9(1): 4366, 2018 10 19.
Article in En | MEDLINE | ID: mdl-30341296

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Synthases / Bacterial Proteins Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Synthases / Bacterial Proteins Type of study: Prognostic_studies Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2018 Type: Article Affiliation country: Germany