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Cortical bone mineral density is increased by the cathepsin K inhibitor ONO-5334, which leads to a robust increase in bone strength: results from a 16-month study in ovariectomised cynomolgus monkeys.
Yamada, Hiroyuki; Ochi, Yasuo; Mori, Hiroshi; Nishikawa, Satoshi; Hashimoto, Yasuaki; Tanaka, Makoto; Deacon, Steve; Kawabata, Kazuhito.
Affiliation
  • Yamada H; Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan. hi.yamada@ono.co.jp.
  • Ochi Y; Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan.
  • Mori H; Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan.
  • Nishikawa S; Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan.
  • Hashimoto Y; Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan.
  • Tanaka M; Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan.
  • Deacon S; Drug Development, ONO Pharma UK LTD, MidCity Place, 71 High Holborn, London, WC1V 6EA, UK.
  • Kawabata K; Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka, 618-8585, Japan.
J Bone Miner Metab ; 37(4): 636-647, 2019 Jul.
Article in En | MEDLINE | ID: mdl-30357565
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovariectomy / Bone Density / Thiazolidines / Cathepsin K / Cortical Bone Limits: Animals / Female / Humans Language: En Journal: J Bone Miner Metab Journal subject: METABOLISMO Year: 2019 Type: Article Affiliation country: Japan
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovariectomy / Bone Density / Thiazolidines / Cathepsin K / Cortical Bone Limits: Animals / Female / Humans Language: En Journal: J Bone Miner Metab Journal subject: METABOLISMO Year: 2019 Type: Article Affiliation country: Japan