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Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Weihofen, Andreas; Liu, YuTing; Arndt, Joseph W; Huy, Christian; Quan, Chao; Smith, Benjamin A; Baeriswyl, Jean-Luc; Cavegn, Nicole; Senn, Luzia; Su, Lihe; Marsh, Galina; Auluck, Pavan K; Montrasio, Fabio; Nitsch, Roger M; Hirst, Warren D; Cedarbaum, Jesse M; Pepinsky, R Blake; Grimm, Jan; Weinreb, Paul H.
Affiliation
  • Weihofen A; Biogen, 225 Binney Street, Cambridge, MA 02142, USA; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland. Electronic address: andreas.weihofen@biogen.com.
  • Liu Y; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Arndt JW; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Huy C; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland.
  • Quan C; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Smith BA; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Baeriswyl JL; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland.
  • Cavegn N; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland.
  • Senn L; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland.
  • Su L; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Marsh G; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Auluck PK; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Montrasio F; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland.
  • Nitsch RM; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland; Institute for Regenerative Medicine, University of Zurich, Wagistrasse 12, 8952 Schlieren, Switzerland.
  • Hirst WD; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Cedarbaum JM; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Pepinsky RB; Biogen, 225 Binney Street, Cambridge, MA 02142, USA.
  • Grimm J; Neurimmune AG, Wagistrasse 13, 8952 Schlieren, Switzerland.
  • Weinreb PH; Biogen, 225 Binney Street, Cambridge, MA 02142, USA. Electronic address: paul.weinreb@biogen.com.
Neurobiol Dis ; 124: 276-288, 2019 04.
Article in En | MEDLINE | ID: mdl-30381260
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinsonian Disorders / Alpha-Synuclein / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2019 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinsonian Disorders / Alpha-Synuclein / Antibodies, Monoclonal Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2019 Type: Article