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Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice.
Rada, Patricia; Mosquera, Alejandra; Muntané, Jordi; Ferrandiz, Francisco; Rodriguez-Mañas, Leocadio; de Pablo, Flora; González-Canudas, Jorge; Valverde, Ángela M.
Affiliation
  • Rada P; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm) (CSIC/UAM), C/ Arturo Duperier 4, 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029 Madrid, Spain.
  • Mosquera A; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm) (CSIC/UAM), C/ Arturo Duperier 4, 28029, Madrid, Spain.
  • Muntané J; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, 28029 Madrid, Spain; Oncology Surgery, Cell Therapy and Transplant Organs, Institute of Biomedicine of Seville (IBiS)/University Hospital Virgen del Rocio/CSIC/University of Sev
  • Ferrandiz F; Laboratorios Silanes, Mexico City, Mexico.
  • Rodriguez-Mañas L; Department of Geriatrics, Hospital Universitario de Getafe and School of Health Sciences, Universidad Europea de Madrid, 28905 Getafe, Spain.
  • de Pablo F; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029 Madrid, Spain; Department of Molecular Biomedicine, Centro de Investigaciones Biológicas (CSIC), Madrid, Spain.
  • González-Canudas J; Laboratorios Silanes, Mexico City, Mexico.
  • Valverde ÁM; Instituto de Investigaciones Biomédicas Alberto Sols (IIBm) (CSIC/UAM), C/ Arturo Duperier 4, 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029 Madrid, Spain. Electronic address: avalverde@iib.uam.es.
Food Chem Toxicol ; 123: 470-480, 2019 Jan.
Article in En | MEDLINE | ID: mdl-30414960
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Diabetes Mellitus, Type 2 / AMP-Activated Protein Kinases / Glucose / Insulin / Metformin Type of study: Clinical_trials / Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Food Chem Toxicol Year: 2019 Type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hepatocytes / Diabetes Mellitus, Type 2 / AMP-Activated Protein Kinases / Glucose / Insulin / Metformin Type of study: Clinical_trials / Diagnostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Food Chem Toxicol Year: 2019 Type: Article Affiliation country: Spain