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SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX.
Eldehna, Wagdy M; Abo-Ashour, Mahmoud F; Berrino, Emanuela; Vullo, Daniela; Ghabbour, Hazem A; Al-Rashood, Sara T; Hassan, Ghada S; Alkahtani, Hamad M; Almehizia, Abdulrahman A; Alharbi, Amal; Abdel-Aziz, Hatem A; Supuran, Claudiu T.
Affiliation
  • Eldehna WM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt. Electronic address: wagdy2000@gmail.com.
  • Abo-Ashour MF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Egyptian Russian University, P.O. Box 11829, Badr City, Cairo, Egypt.
  • Berrino E; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.
  • Vullo D; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy.
  • Ghabbour HA; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
  • Al-Rashood ST; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
  • Hassan GS; Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
  • Alkahtani HM; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
  • Almehizia AA; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
  • Alharbi A; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
  • Abdel-Aziz HA; Department of Applied Organic Chemistry, National Research Center, Dokki, Cairo 12622, Egypt.
  • Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Polo Scientifico, Via U. Schiff 6, 50019 Sesto Fiorentino, Firenze, Italy. Electronic address: claudiu.supuran@unifi.it.
Bioorg Chem ; 83: 549-558, 2019 03.
Article in En | MEDLINE | ID: mdl-30471577
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Carbonic Anhydrase Inhibitors / Carbonic Anhydrase IX / Aniline Compounds / Antigens, Neoplasm Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2019 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sulfonamides / Carbonic Anhydrase Inhibitors / Carbonic Anhydrase IX / Aniline Compounds / Antigens, Neoplasm Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2019 Type: Article