Gait speed and prognosis in patients with idiopathic pulmonary fibrosis: a prospective cohort study.
Eur Respir J
; 53(2)2019 02.
Article
in En
| MEDLINE
| ID: mdl-30487200
ABSTRACT
The 4-m gait speed (4MGS), a simple physical performance measure and surrogate marker of frailty, consistently predicts adverse prognosis in older adults. We hypothesised that 4MGS could predict all-cause mortality and nonelective hospitalisation in patients with idiopathic pulmonary fibrosis (IPF).4MGS and lung function were measured at baseline in 130 outpatients newly diagnosed with IPF. Survival status and nonelective hospital admissions were recorded over 1â
year. We assessed the predictive value of 4MGS (as a continuous variable and as a binary variable slow versus preserved 4MGS) by calculating hazard ratios using Cox proportional regression, adjusting for potential confounding variables. Receiver operating characteristic curves assessed discrimination between the multivariable regression models and established prognostic indices.Continuous 4MGS and slow 4MGS were independent predictors of all-cause mortality (4MGS HR 0.03, 95% CI 0.01-0.31; p=0.004; slow 4MGS 2.63, 95% CI 1.01-6.87; p=0.049) and hospitalisation (4MGS HR 0.02, 95% CI 0.01-0.14; p<0.001; slow 4MGS 2.76, 95% CI 1.16-6.58; p=0.02). Multivariable models incorporating 4MGS or slow 4MGS had better discrimination for predicting mortality than either the gender, age and lung physiology index or Composite Physiologic Index.In patients with IPF, 4MGS is an independent predictor of all-cause mortality and nonelective hospitalisation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Idiopathic Pulmonary Fibrosis
/
Walking Speed
/
Gait
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Eur Respir J
Year:
2019
Type:
Article
Affiliation country:
United kingdom