Effect of mesenchymal stromal (stem) cell (MSC) transplantation in asthmatic animal models: A systematic review and meta-analysis.
Pulm Pharmacol Ther
; 54: 39-52, 2019 02.
Article
in En
| MEDLINE
| ID: mdl-30496803
ABSTRACT
BACKGROUND:
Over the years, mesenchymal stromal (stem) cells (MSCs) have been pre-clinically applied in the treatment of variety kinds of diseases including asthma and chronic lung diseases. Aim of the current study was to systematically review and to conduct meta-analysis on the published studies of MSC treatment in asthma animal models.METHODS:
Publications on the MSC and asthma treatment was thoroughly searched in the electronic databases. Statistical analysis was then performed using the Comprehensive Meta-Analysis software (Version 3). Effect of MSC therapy on asthma model was assessed by Hedges's g with 95% confidence intervals (95% CIs). Random effect model was used due to the heterogeneity between the studies.RESULTS:
Meta-analysis of the 32 included studies showed that MSC transplantation was significantly in favor of attenuating lung injury and remodeling (Hedges's gâ¯=â¯-9.104⯱â¯0.951 with 95% CI -10.969â¯â¼â¯-7.240, Pâ¯<â¯0.001) and airway inflammation (Hedges's gâ¯=â¯-4.146⯱â¯0.688 with 95% CI -5.495â¯â¼â¯-2.797, Pâ¯<â¯0.001). The mechanism of MSC therapy in asthma seems to be regulating the balance of Th1 cytokine and Th2 cytokines (IFN-γ Hedges's gâ¯=â¯4.779⯱â¯1.408 with 95% CI 1.099-2.725, Pâ¯<â¯0.001; IL-4 Hedges's gâ¯=â¯-10.781⯱â¯1.062 with 95% CI -12.863â¯â¼â¯-8.699, Pâ¯<â¯0.001; IL-5 Hedges's gâ¯=â¯-10.537⯱â¯1.269 with 95% CI -13.025â¯â¼â¯-8.050, Pâ¯<â¯0.001; IL-13 Hedges's gâ¯=â¯-6.773⯱â¯0.788 with 95% CI -8.318â¯â¼â¯-5.229, Pâ¯<â¯0.001).CONCLUSION:
Findings of the current systemic review suggested a potential role for MSCs in asthma treatment although it is still challenging in clinical practice. The mechanisms of MSCs in pre-clinical asthma treatment may be associated with attenuating airway inflammation through regulating Th1 and Th2 cytokines.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Asthma
/
Cytokines
/
Mesenchymal Stem Cell Transplantation
Type of study:
Prognostic_studies
/
Systematic_reviews
Limits:
Animals
/
Humans
Language:
En
Journal:
Pulm Pharmacol Ther
Journal subject:
FARMACOLOGIA
Year:
2019
Type:
Article
Affiliation country:
China