Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder.
Braz J Psychiatry
; 41(3): 254-256, 2019.
Article
in En
| MEDLINE
| ID: mdl-30540025
ABSTRACT
OBJECTIVE:
Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.METHODS:
In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Volumetric measurements of the anterior cingulate cortex (ACC), lateral ventricles, amygdala, and hippocampus were completed using the automated software FreeSurfer.RESULTS:
Analysis of covariance (with age, gender, and intracranial volume as covariates) indicated smaller left ACC volumes in unaffected relatives as compared to healthy controls and BD patients (p = 0.004 and p = 0.037, respectively). No additional statistically significant differences were detected for other brain structures.CONCLUSION:
Our findings suggest smaller left ACC volume as a viable biomarker candidate for BD.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Bipolar Disorder
/
Gyrus Cinguli
/
Hippocampus
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Braz J Psychiatry
Journal subject:
PSIQUIATRIA
Year:
2019
Type:
Article
Affiliation country:
United States