Comparative effects of scopolamine and phencynonate on organophosphorus nerve agent-induced seizure activity, neuropathology and lethality.

Shih, Tsung-Ming; Koenig, Jeffrey A; Acon Chen, Cindy

Shih, Tsung-Ming; Koenig, Jeffrey A; Acon Chen, Cindy.

Affiliation

Shih TM; a Medical Toxicology Research Division , US Army Medical Research Institute of Chemical Defense , Edgewood , MD , USA.
Koenig JA; a Medical Toxicology Research Division , US Army Medical Research Institute of Chemical Defense , Edgewood , MD , USA.
Acon Chen C; a Medical Toxicology Research Division , US Army Medical Research Institute of Chemical Defense , Edgewood , MD , USA.

Toxicol Mech Methods ; 29(5): 322-333, 2019 Jun.

Article in En | MEDLINE | ID: mdl-30558458

Subject(s)

Anticonvulsants/pharmacology; Aza Compounds/pharmacology; Brain/drug effects; Glycolates/pharmacology; Nerve Agents/toxicity; Organophosphorus Compounds/toxicity; Scopolamine/pharmacology; Seizures/prevention & control; Age of Onset; Animals; Anticonvulsants/administration & dosage; Aza Compounds/administration & dosage; Brain/pathology; Disease Models, Animal; Dose-Response Relationship, Drug; Glycolates/administration & dosage; Guinea Pigs; Lethal Dose 50; Male; Scopolamine/administration & dosage; Seizures/chemically induced; Seizures/pathology

Key words

Phencynonate; VR; VX; cyclosarin; lethality; nerve agents; neuropathology; organophosphorus compounds; sarin; scopolamine; seizure activity; soman; tabun

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Organophosphorus Compounds / Scopolamine / Seizures / Aza Compounds / Brain / Nerve Agents / Glycolates / Anticonvulsants Limits: Animals Language: En Journal: Toxicol Mech Methods Journal subject: TOXICOLOGIA Year: 2019 Type: Article Affiliation country: United States

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