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Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model.
Yin, Changtian; Dai, Xuanxuan; Huang, Xiangjie; Zhu, Wangyu; Chen, Xi; Zhou, Qiulin; Wang, Canwei; Zhao, Chengguang; Zou, Peng; Liang, Guang; Rajamanickam, Vinothkumar; Wang, Ouchen; Zhang, Xiaohua; Cui, Ri.
Affiliation
  • Yin C; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Dai X; Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Huang X; Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zhu W; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Chen X; Cell and Molecular Biology Laboratory, Zhoushan Hospital of Wenzhou Medical University, Zhoushan, Zhejiang, China.
  • Zhou Q; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Wang C; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zhao C; Affiliated Yueqing Hospital and School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zou P; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Liang G; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Rajamanickam V; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Wang O; Chemical Biology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Zhang X; Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
  • Cui R; Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
J Cell Mol Med ; 23(3): 2194-2206, 2019 03.
Article in En | MEDLINE | ID: mdl-30609207
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxin-Disulfide Reductase / Apoptosis / Xenograft Model Antitumor Assays / Sesquiterpenes, Eudesmane / Thioredoxin Reductase 1 / Endoplasmic Reticulum Stress / Triple Negative Breast Neoplasms / Lactones Limits: Animals / Female / Humans Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thioredoxin-Disulfide Reductase / Apoptosis / Xenograft Model Antitumor Assays / Sesquiterpenes, Eudesmane / Thioredoxin Reductase 1 / Endoplasmic Reticulum Stress / Triple Negative Breast Neoplasms / Lactones Limits: Animals / Female / Humans Language: En Journal: J Cell Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2019 Type: Article Affiliation country: China