Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats.

Zhang, Chang-Xiong; Cheng, Ying; Liu, Dao-Zhou; Liu, Miao; Cui, Han; Zhang, Bang-le; Mei, Qi-Bing; Zhou, Si-Yuan

Zhang, Chang-Xiong; Cheng, Ying; Liu, Dao-Zhou; Liu, Miao; Cui, Han; Zhang, Bang-le; Mei, Qi-Bing; Zhou, Si-Yuan.

Affiliation

Zhang CX; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Cheng Y; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Liu DZ; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Liu M; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Cui H; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Zhang BL; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Mei QB; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China.
Zhou SY; Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Changle West Road 169, Xi'an, 710032, Shaanxi, China. zhousy@fmmu.edu.cn.

J Nanobiotechnology ; 17(1): 18, 2019 Jan 25.

Article in En | MEDLINE | ID: mdl-30683110

Subject(s)

Cyclosporine/administration & dosage; Cyclosporine/chemistry; Drug Carriers/chemistry; Drug Delivery Systems; Mitochondria/metabolism; Myocardial Reperfusion Injury/drug therapy; Oligopeptides/chemistry; Animals; Apoptosis/drug effects; Cell Line; Cyclosporine/pharmacokinetics; Cyclosporine/pharmacology; Disease Models, Animal; Drug Carriers/administration & dosage; Drug Carriers/pharmacokinetics; Drug Carriers/pharmacology; Mitochondria/drug effects; Mitochondria/pathology; Mitochondrial Membrane Transport Proteins/drug effects; Mitochondrial Permeability Transition Pore; Myocardium/metabolism; Myocardium/pathology; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; Particle Size; Rats

Key words

Cyclosporin A; Mitochondria-targeted peptide; Mitochondrial permeability transition pore; Mitochondrial targeting; Myocardial ischemia/reperfusion injury

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Drug Carriers / Myocardial Reperfusion Injury / Drug Delivery Systems / Cyclosporine / Mitochondria Limits: Animals Language: En Journal: J Nanobiotechnology Year: 2019 Type: Article Affiliation country: China

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