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IL-17 and colorectal cancer: From carcinogenesis to treatment.
Razi, Sepideh; Baradaran Noveiry, Behnoud; Keshavarz-Fathi, Mahsa; Rezaei, Nima.
Affiliation
  • Razi S; Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Baradaran Noveiry B; Division of Cardiology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Baltimore, MD, USA.
  • Keshavarz-Fathi M; Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Scien
  • Rezaei N; Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Cancer Immunology Project (CIP), Universal Scientific Education and Research Netw
Cytokine ; 116: 7-12, 2019 04.
Article in En | MEDLINE | ID: mdl-30684916
ABSTRACT
Colorectal cancer (CRC) is one of the most common types of cancer in the world. Several factors contribute to the development of this cancer. Tumor formation in colon triggers immune responses such as immune cells proliferation, phenotype alteration, cytokine synthesis and release, which lead to IL-17 producing T cells, the differentiated CD4+ T cells i.e. T helper 17. IL-17 is a pro-inflammatory cytokine, which its level is up regulated in serum and tissues of CRC patients. Several studies have shown that IL-17 has an important role in metastasis and prognosis of CRC. The aim of this review is to summarize the role of this cytokine in tumorigenesis, angiogenesis and metastasis of CRC and discuss its value in diagnosis, prognosis and treatment of CRC.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Interleukin-17 / Carcinogenesis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Type: Article Affiliation country: Iran
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Interleukin-17 / Carcinogenesis Type of study: Prognostic_studies Limits: Humans Language: En Journal: Cytokine Journal subject: ALERGIA E IMUNOLOGIA Year: 2019 Type: Article Affiliation country: Iran