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A novel method using nuclear magnetic resonance for plasma protein binding assessment in drug discovery programs.
Gallo, Mariana; Matteucci, Sara; Alaimo, Nadine; Pitti, Erica; Orsale, Maria V; Summa, Vincenzo; Cicero, Daniel O; Monteagudo, Edith.
Affiliation
  • Gallo M; IRBM Science Park S.p.A., Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.
  • Matteucci S; Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma "Tor Vergata", Via della Ricerca Scientifica, 00133, Rome, Italy.
  • Alaimo N; Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma "Tor Vergata", Via della Ricerca Scientifica, 00133, Rome, Italy.
  • Pitti E; Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma "Tor Vergata", Via della Ricerca Scientifica, 00133, Rome, Italy.
  • Orsale MV; IRBM Science Park S.p.A., Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.
  • Summa V; IRBM Science Park S.p.A., Via Pontina km 30.600, 00071, Pomezia, Rome, Italy.
  • Cicero DO; IRBM Science Park S.p.A., Via Pontina km 30.600, 00071, Pomezia, Rome, Italy; Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma "Tor Vergata", Via della Ricerca Scientifica, 00133, Rome, Italy. Electronic address: cicero@scienze.uniroma2.it.
  • Monteagudo E; IRBM Science Park S.p.A., Via Pontina km 30.600, 00071, Pomezia, Rome, Italy. Electronic address: e.monteagudo@irbm.it.
J Pharm Biomed Anal ; 167: 21-29, 2019 Apr 15.
Article in En | MEDLINE | ID: mdl-30738240
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Blood Proteins / Nuclear Magnetic Resonance, Biomolecular / Drug Discovery Limits: Humans Language: En Journal: J Pharm Biomed Anal Year: 2019 Type: Article Affiliation country: Italy
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Blood Proteins / Nuclear Magnetic Resonance, Biomolecular / Drug Discovery Limits: Humans Language: En Journal: J Pharm Biomed Anal Year: 2019 Type: Article Affiliation country: Italy