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Inherited Interleukin 2-Inducible T-Cell (ITK) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma.
Youssefian, Leila; Vahidnezhad, Hassan; Yousefi, Mehdi; Saeidian, Amir Hossein; Azizpour, Arghavan; Touati, Andrew; Nikbakht, Neda; Hesari, Kambiz Kamyab-; Adib-Sereshki, Mohammad Mahdi; Zeinali, Sirous; Mansoori, Behzad; Jazayeri, Ali; Karamzadeh, Razieh; Fortina, Paolo; Jouanguy, Emmanuelle; Casanova, Jean-Laurent; Uitto, Jouni.
Affiliation
  • Youssefian L; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Vahidnezhad H; Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Iran.
  • Yousefi M; Genetics, Genomics and Cancer Biology PhD Program, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Saeidian AH; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Azizpour A; Biotechnology Research Center, Department of Molecular Medicine, Pasteur Institute of Iran, Tehran.
  • Touati A; Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Iran.
  • Nikbakht N; Drug Applied Research Center, Tabriz University of Medical Sciences, Tehran University of Medical Sciences, Iran.
  • Hesari KK; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Adib-Sereshki MM; Genetics, Genomics and Cancer Biology PhD Program, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Zeinali S; Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Iran.
  • Mansoori B; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Jazayeri A; Drexel University College of Medicine, Philadelphia, Pennsylvania.
  • Karamzadeh R; Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Fortina P; Department of Pathology, Razi Hospital, Tehran University of Medical Sciences, Tehran.
  • Jouanguy E; Gastrointestinal and Liver Diseases Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran.
  • Casanova JL; Biotechnology Research Center, Department of Molecular Medicine, Pasteur Institute of Iran, Tehran.
  • Uitto J; Kawsar Human Genetics Research Center, Tehran.
Clin Infect Dis ; 68(11): 1938-1941, 2019 05 17.
Article in En | MEDLINE | ID: mdl-30778533
Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with ß-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including ß-HPV and EBV.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epidermodysplasia Verruciformis / Protein-Tyrosine Kinases / Hodgkin Disease / T-Lymphocytes / Loss of Function Mutation Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2019 Type: Article
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epidermodysplasia Verruciformis / Protein-Tyrosine Kinases / Hodgkin Disease / T-Lymphocytes / Loss of Function Mutation Type of study: Prognostic_studies Limits: Adult / Female / Humans / Male Language: En Journal: Clin Infect Dis Journal subject: DOENCAS TRANSMISSIVEIS Year: 2019 Type: Article