Neutrophils Derived from Genetically Modified Human Induced Pluripotent Stem Cells Circulate and Phagocytose Bacteria In Vivo.

Trump, Lisa R; Nayak, Ramesh C; Singh, Abhishek K; Emberesh, Sana; Wellendorf, Ashley M; Lutzko, Carolyn M; Cancelas, Jose A

Trump, Lisa R; Nayak, Ramesh C; Singh, Abhishek K; Emberesh, Sana; Wellendorf, Ashley M; Lutzko, Carolyn M; Cancelas, Jose A.

Affiliation

Trump LR; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Nayak RC; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Singh AK; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Emberesh S; Hoxworth Blood Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Wellendorf AM; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Lutzko CM; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Cancelas JA; Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

Stem Cells Transl Med ; 8(6): 557-567, 2019 06.

Article in En | MEDLINE | ID: mdl-30793529

Subject(s)

Neutrophils/immunology; Phagocytosis; Adult; Animals; Escherichia coli/pathogenicity; Extracellular Traps/drug effects; Extracellular Traps/metabolism; Female; Granulocyte Colony-Stimulating Factor/pharmacology; Humans; Induced Pluripotent Stem Cells/cytology; Induced Pluripotent Stem Cells/metabolism; Male; Mice; Neutrophils/cytology; Neutrophils/metabolism; Neutrophils/transplantation; Peritonitis/pathology; Peritonitis/therapy; Proto-Oncogene Proteins c-akt/agonists; Proto-Oncogene Proteins c-akt/genetics; Proto-Oncogene Proteins c-akt/metabolism; Reactive Oxygen Species/metabolism; Signal Transduction; Tetradecanoylphorbol Acetate/pharmacology

Key words

AKT; Circulation; Human induced pluripotent stem cells; Neutrophils; Phagocytosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Neutrophils Type of study: Prognostic_studies Limits: Adult / Animals / Female / Humans / Male Language: En Journal: Stem Cells Transl Med Year: 2019 Type: Article Affiliation country: United States

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