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Formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation.
Appel, Mason J; Meier, Katlyn K; Lafrance-Vanasse, Julien; Lim, Hyeongtaek; Tsai, Chi-Lin; Hedman, Britt; Hodgson, Keith O; Tainer, John A; Solomon, Edward I; Bertozzi, Carolyn R.
Affiliation
  • Appel MJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
  • Meier KK; Department of Chemistry, Stanford University, Stanford, CA 94305.
  • Lafrance-Vanasse J; Department of Chemistry, Stanford University, Stanford, CA 94305.
  • Lim H; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.
  • Tsai CL; Department of Chemistry, Stanford University, Stanford, CA 94305.
  • Hedman B; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
  • Hodgson KO; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Tainer JA; Department of Chemistry, Stanford University, Stanford, CA 94305.
  • Solomon EI; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025.
  • Bertozzi CR; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720; jtainer@mdanderson.org edward.solomon@stanford.edu bertozzi@stanford.edu.
Proc Natl Acad Sci U S A ; 116(12): 5370-5375, 2019 03 19.
Article in En | MEDLINE | ID: mdl-30824597

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Copper / Glycine Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oxygen / Copper / Glycine Language: En Journal: Proc Natl Acad Sci U S A Year: 2019 Type: Article