Inhibiting Sphingosine Kinase 2 Derived-sphingosine-1-phosphate Ameliorates Psoriasis-like Skin Disease via Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes in Mice.

Shin, Sun-Hye; Cho, Kyung-Ah; Hahn, Soojung; Lee, Younghay; Kim, Yu-He; Woo, So-Youn; Ryu, Kyung-Ha; Park, Woo-Jae; Park, Joo-Won

Shin, Sun-Hye; Cho, Kyung-Ah; Hahn, Soojung; Lee, Younghay; Kim, Yu-He; Woo, So-Youn; Ryu, Kyung-Ha; Park, Woo-Jae; Park, Joo-Won.

Affiliation

Shin SH; Department of Biochemistry, School of medicine, Ewha Womans University, 07985 Seoul, Korea.

Acta Derm Venereol ; 99(6): 594-601, 2019 May 01.

Article in En | MEDLINE | ID: mdl-30834454

Subject(s)

CD4-Positive T-Lymphocytes/physiology; Enzyme Inhibitors/pharmacology; Lysophospholipids/biosynthesis; Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors; Psoriasis/drug therapy; Sphingosine/analogs & derivatives; Administration, Topical; Animals; Cell Differentiation/drug effects; Ceramidases/antagonists & inhibitors; Disease Models, Animal; Gene Expression/drug effects; Imiquimod; Immunity/drug effects; Inflammation/genetics; Interleukin-17/blood; Male; Mice; Psoriasis/chemically induced; Psoriasis/pathology; Quinolones/pharmacology; RNA, Messenger/metabolism; Sphingosine/biosynthesis; Suppressor of Cytokine Signaling 1 Protein; Th17 Cells

Key words

CD4+ T lymphocyte; Th17 differentiation; psoriasis; sphingosine kinase; sphingosine-1-phosphate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psoriasis / Sphingosine / Lysophospholipids / CD4-Positive T-Lymphocytes / Phosphotransferases (Alcohol Group Acceptor) / Enzyme Inhibitors Limits: Animals Language: En Journal: Acta Derm Venereol Year: 2019 Type: Article

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