Lewis base catalyzed regioselective cyclization of allene ketones or α-methyl allene ketones with unsaturated pyrazolones.
Org Biomol Chem
; 17(12): 3232-3238, 2019 Mar 20.
Article
in En
| MEDLINE
| ID: mdl-30840009
ABSTRACT
A nitrogen-containing Lewis base catalyzed highly regioselective [4 + 2] cycloaddition of allene ketones or α-methyl allene ketones with unsaturated pyrazolones has been disclosed to give the corresponding tetrahydropyrano [2,3-c] pyrazoles in moderate to good yields under mild conditions. High regioselectivity, 100% atom-economy, broad substrate scope and good functional group tolerance are attractive features of this process and make it a practical and versatile transformation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Biomol Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2019
Type:
Article
Affiliation country:
China