Generalization of learned responses in the mormyrid electrosensory lobe.
Elife
; 82019 03 14.
Article
in En
| MEDLINE
| ID: mdl-30860480
ABSTRACT
Appropriate generalization of learned responses to new situations is vital for adaptive behavior. We provide a circuit-level account of generalization in the electrosensory lobe (ELL) of weakly electric mormyrid fish. Much is already known in this system about a form of learning in which motor corollary discharge signals cancel responses to the uninformative input evoked by the fish's own electric pulses. However, for this cancellation to be useful under natural circumstances, it must generalize accurately across behavioral regimes, specifically different electric pulse rates. We show that such generalization indeed occurs in ELL neurons, and develop a circuit-level model explaining how this may be achieved. The mechanism involves regularized synaptic plasticity and an approximate matching of the temporal dynamics of motor corollary discharge and electrosensory inputs. Recordings of motor corollary discharge signals in mossy fibers and granule cells provide direct evidence for such matching.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Perception
/
Electric Fish
/
Adaptation, Psychological
/
Electricity
/
Cerebrum
/
Generalization, Psychological
/
Learning
Limits:
Animals
Language:
En
Journal:
Elife
Year:
2019
Type:
Article
Affiliation country:
United States