Novel fused 1,2,3-triazolo-benzodiazepine derivatives as potent anticonvulsant agents: design, synthesis, in vivo, and in silico evaluations.

Shafie, Arefeh; Mohammadi-Khanaposhtani, Maryam; Asadi, Mehdi; Rahimi, Nastaran; Ranjbar, Parviz Rashidi; Ghasemi, Jahan B; Larijani, Bagher; Mahdavi, Mohammad; Shafaroodi, Hamed; Dehpour, Ahmad Reza

Shafie, Arefeh; Mohammadi-Khanaposhtani, Maryam; Asadi, Mehdi; Rahimi, Nastaran; Ranjbar, Parviz Rashidi; Ghasemi, Jahan B; Larijani, Bagher; Mahdavi, Mohammad; Shafaroodi, Hamed; Dehpour, Ahmad Reza.

Affiliation

Shafie A; School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Mohammadi-Khanaposhtani M; Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Asadi M; Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Rahimi N; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Ranjbar PR; School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Ghasemi JB; School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
Larijani B; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Mahdavi M; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Momahdavi@sina.tums.ac.ir.
Shafaroodi H; Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran.
Dehpour AR; Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran. dehpour@sina.tums.ac.ir.

Mol Divers ; 24(1): 179-189, 2020 Feb.

Article in En | MEDLINE | ID: mdl-30895449

Subject(s)

Anticonvulsants/chemistry; Anticonvulsants/pharmacology; Benzodiazepines/chemistry; Benzodiazepines/pharmacology; Triazoles/chemistry; Anticonvulsants/chemical synthesis; Benzodiazepines/chemical synthesis; Binding Sites; Chemistry Techniques, Synthetic; Drug Design; GABA-A Receptor Antagonists/chemistry; GABA-A Receptor Antagonists/pharmacology; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Quantitative Structure-Activity Relationship; Receptors, GABA-A/chemistry; Seizures/drug therapy; Seizures/etiology

Key words

1,2,3-Triazolo-benzodiazepine; Anticonvulsant; Docking study; Seizure

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triazoles / Benzodiazepines / Anticonvulsants Type of study: Etiology_studies Language: En Journal: Mol Divers Journal subject: BIOLOGIA MOLECULAR Year: 2020 Type: Article Affiliation country: Iran

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