Disease mechanisms and neuroprotection by tauroursodeoxycholic acid in Rpgr knockout mice.

Zhang, Xun; Shahani, Uma; Reilly, James; Shu, Xinhua

Zhang, Xun; Shahani, Uma; Reilly, James; Shu, Xinhua.

Affiliation

Zhang X; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, Scotland.
Shahani U; Department of Vision Science, Glasgow Caledonian University, Glasgow, Scotland.
Reilly J; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, Scotland.
Shu X; Department of Biological and Biomedical Sciences, Glasgow Caledonian University, Glasgow, Scotland.

J Cell Physiol ; 234(10): 18801-18812, 2019 08.

Article in En | MEDLINE | ID: mdl-30924157

Subject(s)

DNA-Binding Proteins/deficiency; Neuroprotection; Taurochenodeoxycholic Acid/pharmacology; Animals; Apoptosis/drug effects; Cilia/drug effects; Cilia/pathology; DNA-Binding Proteins/metabolism; Disease Models, Animal; Eye Proteins/metabolism; Mice, Knockout; Microglia/drug effects; Microglia/pathology; Neuroprotection/drug effects; Photoreceptor Cells, Vertebrate/pathology; Retina/drug effects; Retina/pathology; Retinal Degeneration/pathology

Key words

RPGR; microglia activation; neuroprotection; retinitis pigmentosa; tauroursodeoxycholic acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Taurochenodeoxycholic Acid / DNA-Binding Proteins / Neuroprotection Limits: Animals Language: En Journal: J Cell Physiol Year: 2019 Type: Article Affiliation country: United kingdom

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