Notch3 signaling activation in smooth muscle cells promotes extrauterine growth restriction-induced pulmonary hypertension.

Wang, Y; Dai, S; Cheng, X; Prado, E; Yan, L; Hu, J; He, Q; Lv, Y; Lv, Y; Du, L

Wang, Y; Dai, S; Cheng, X; Prado, E; Yan, L; Hu, J; He, Q; Lv, Y; Lv, Y; Du, L.

Affiliation

Wang Y; Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Dai S; Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Cheng X; Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Prado E; Loma Linda University School of Medicine, Loma Linda, CA, USA.
Yan L; Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Hu J; Department of Surgical Intensive Care Unit, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
He Q; Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Lv Y; Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Lv Y; Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Du L; Department of Pediatrics, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, China. Electronic address: dulizhong@zju.edu.cn.

Nutr Metab Cardiovasc Dis ; 29(6): 639-651, 2019 06.

Article in En | MEDLINE | ID: mdl-30954415

Subject(s)

Arterial Pressure; Growth Disorders/complications; Hypertension, Pulmonary/etiology; Muscle, Smooth, Vascular/metabolism; Myocytes, Smooth Muscle/metabolism; Receptor, Notch3/metabolism; Animals; Animals, Newborn; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Caloric Restriction; Cell Movement; Cell Proliferation; Disease Models, Animal; Growth Disorders/metabolism; Hypertension, Pulmonary/metabolism; Hypertension, Pulmonary/pathology; Hypertension, Pulmonary/physiopathology; Male; Muscle, Smooth, Vascular/pathology; Myocytes, Smooth Muscle/pathology; Pulmonary Artery/metabolism; Pulmonary Artery/pathology; Pulmonary Artery/physiopathology; Rats, Sprague-Dawley; Receptor, Notch3/genetics; Repressor Proteins/genetics; Repressor Proteins/metabolism; Signal Transduction; Vascular Remodeling

Key words

Extrauterine growth restriction; Notch3 signaling pathway; Pulmonary artery smooth muscle cells; Pulmonary hypertension

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Myocytes, Smooth Muscle / Arterial Pressure / Receptor, Notch3 / Growth Disorders / Hypertension, Pulmonary / Muscle, Smooth, Vascular Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nutr Metab Cardiovasc Dis Journal subject: ANGIOLOGIA / CARDIOLOGIA / CIENCIAS DA NUTRICAO / METABOLISMO Year: 2019 Type: Article Affiliation country: China

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