Lymphomatoid papulosis type E with a CD56+ immunophenotype presenting with purpura-like lesions.
J Cutan Pathol
; 46(7): 542-545, 2019 Jul.
Article
in En
| MEDLINE
| ID: mdl-30957244
ABSTRACT
Lymphomatoid papulosis (LyP) type E is a recently described variant characterized by the occurrence of large necrotic eschar-like lesions displaying microscopically angioinvasive and angiodestructive infiltrates of CD30+ lymphocytes, frequently coexpressing CD8. Rare cases of LyP type E with a CD56+ immunophenotype have been described. Herein, we describe a 36-year-old woman with LyP type E, characterized by purpura-like lesions on her left ankle. Initially, she presented with left ankle swelling, petechiae and ecchymosis, and rapidly developing necrotic papules, all of which resolved spontaneously over a period of a few months without intentional therapy. Biopsy revealed CD30 and CD56 positive atypical cell infiltrates with marked angiocentricity and angiodestruction. Awareness of this rare LyP variant and its correct recognition, even if the clinical presentation is unusual, is important to avoid aggressive treatment.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Purpura
/
Skin Neoplasms
/
Lymphomatoid Papulosis
/
CD56 Antigen
/
Neoplasm Proteins
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
J Cutan Pathol
Year:
2019
Type:
Article
Affiliation country:
China