Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration.

Samarajeewa, Anshula; Jacques, Bonnie E; Dabdoub, Alain

Samarajeewa, Anshula; Jacques, Bonnie E; Dabdoub, Alain.

Affiliation

Samarajeewa A; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Jacques BE; Otonomy Inc., San Diego, CA, USA.
Dabdoub A; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A8, Canada; Biological Sciences, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Otolaryngology - Head & Neck Surgery, University of Toronto, Toronto, ON M5G 2C4, Canada. Electronic address: alain.dabdoub@sri.utoronto.ca.

Mol Ther ; 27(5): 904-911, 2019 05 08.

Article in En | MEDLINE | ID: mdl-30982678

Subject(s)

Hearing Loss/genetics; Receptors, Notch/genetics; Sensation Disorders/genetics; Wnt Signaling Pathway/genetics; Animals; Cochlea/pathology; Epigenesis, Genetic/genetics; Hair Cells, Auditory/pathology; Hearing Loss/pathology; Hearing Loss/therapy; Humans; Mechanoreceptors/pathology; Mice; Sensation Disorders/pathology; Sensation Disorders/therapy

Key words

CRISPR-Cas9; clinical trials; development; epigenetics; mouse cochlea; regeneration; regenerative medicine

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sensation Disorders / Receptors, Notch / Wnt Signaling Pathway / Hearing Loss Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2019 Type: Article Affiliation country: Canada

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