The Promise of Anti-idiotype Revisited.
Front Immunol
; 10: 808, 2019.
Article
in En
| MEDLINE
| ID: mdl-31031777
ABSTRACT
The promise of idiotype-based therapeutics has been disappointing forcing a new look at the concept and its potential to generate an effective approach for immunotherapy. Here, the idiotype network theory is revisited with regard to the development of efficacious anti-idiotype vaccines. The experience of polyclonal anti-Idiotype reagents in animal models as well as an understanding of the immune response in humans lends to the proposition that polyclonal anti-Idiotype vaccines will be more effective compared to monoclonal-based anti-Idiotype vaccines. This novel strategy can be adapted in Biotech-standard production of therapeutic antibodies.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Antibodies, Anti-Idiotypic
/
Immunoglobulin Idiotypes
Limits:
Animals
/
Humans
Language:
En
Journal:
Front Immunol
Year:
2019
Type:
Article
Affiliation country:
United States