Dietary N-Carbamylglutamate (NCG) alleviates liver metabolic disease and hepatocyte apoptosis by suppressing ERK1/2-mTOR-S6K1 signal pathway via promoting endogenous arginine synthesis in Japanese seabass (Lateolabrax japonicus).

Huang, H Y; Chen, P; Liang, X F; Wu, X F; Gu, X; Xue, M

Huang, H Y; Chen, P; Liang, X F; Wu, X F; Gu, X; Xue, M.

Affiliation

Huang HY; National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Chen P; National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Liang XF; National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Wu XF; National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
C P Wang; Beijing Animore Sci. & Tech. Co., Ltd, Beijing, 100193, China.
Gu X; National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. Electronic address: guxu@caas.cn.
Xue M; National Aquafeed Safety Assessment Center, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China; Key Laboratory of Feed Biotechnology of Ministry of Agriculture, Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100081, China; National

Fish Shellfish Immunol ; 90: 338-348, 2019 Jul.

Article in En | MEDLINE | ID: mdl-31075404

Subject(s)

Bass; Fish Diseases/prevention & control; Glutamates/metabolism; Liver Diseases/veterinary; Metabolic Diseases/veterinary; Animal Feed/analysis; Animals; Apoptosis/drug effects; Arginine/biosynthesis; Diet/veterinary; Dietary Supplements/analysis; Dose-Response Relationship, Drug; Fish Diseases/immunology; Fish Proteins/genetics; Fish Proteins/metabolism; Glutamates/administration & dosage; Hepatocytes/drug effects; Liver Diseases/immunology; Liver Diseases/prevention & control; Metabolic Diseases/immunology; Metabolic Diseases/prevention & control; Nutrients/metabolism; Random Allocation; Signal Transduction/drug effects

Key words

Endogenous argsynthesis; Immune and anti-apoptotic response; Lateolabrax japonicus; Lipid metabolism; N-Carbamylglutamate

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bass / Fish Diseases / Glutamates / Liver Diseases / Metabolic Diseases Limits: Animals Language: En Journal: Fish Shellfish Immunol Journal subject: BIOLOGIA / MEDICINA VETERINARIA Year: 2019 Type: Article Affiliation country: China

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