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A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair.
Song, Zhiwang; Tu, Xinyi; Zhou, Qin; Huang, Jinzhou; Chen, Yuping; Liu, Jiaqi; Lee, SeungBaek; Kim, Wootae; Nowsheen, Somaira; Luo, Kuntian; Yuan, Jian; Lou, Zhenkun.
Affiliation
  • Song Z; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Tu X; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Zhou Q; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Huang J; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Chen Y; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Liu J; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Lee S; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Kim W; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA.
  • Nowsheen S; Medical Scientist Training Program, Mayo Clinic Alix School of Medicine, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, 55905, USA.
  • Luo K; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. Luo.kuntian@mayo.edu.
  • Yuan J; Department of Molecular Pharmacology, Mayo Clinic, Rochester, MN, USA. Luo.kuntian@mayo.edu.
  • Lou Z; Division of Oncology Research, Mayo Clinic, Rochester, MN, USA. Yuan.jian@mayo.edu.
Cell Death Dis ; 10(6): 398, 2019 05 21.
Article in En | MEDLINE | ID: mdl-31113933
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorylcholine / Phthalazines / Piperazines / Ubiquitin Thiolesterase / Recombinational DNA Repair / Poly(ADP-ribose) Polymerase Inhibitors / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Cell Death Dis Year: 2019 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphorylcholine / Phthalazines / Piperazines / Ubiquitin Thiolesterase / Recombinational DNA Repair / Poly(ADP-ribose) Polymerase Inhibitors / Antineoplastic Agents Limits: Animals / Female / Humans Language: En Journal: Cell Death Dis Year: 2019 Type: Article Affiliation country: United States