Toward Rational Design of Novel Anti-Cancer Drugs Based on Targeting, Solubility, and Bioavailability Exemplified by 1,3,4-Thiadiazole Derivatives Synthesized Under Solvent-Free Conditions.

Rashdan, Huda R M; Farag, Mohammad M; El-Gendey, Marwa S; Mounier, Marwa M

Rashdan, Huda R M; Farag, Mohammad M; El-Gendey, Marwa S; Mounier, Marwa M.

Affiliation

Rashdan HRM; Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo 12622, Egypt. hr.rashdan@nrc.sci.eg.
Farag MM; Glass Research Department, National Research Centre, 33 El-Behooth Str., Dokki, Cairo 12622, Egypt.
El-Gendey MS; Chemistry Department, Faculty of Science "Girls", Al-Azhar University, Cairo 11754, Egypt.
Mounier MM; Chemistry Department, Faculty of College, Turabah, Taif University, Taif 21974, Saudi Arabia.

Molecules ; 24(13)2019 Jun 27.

Article in En | MEDLINE | ID: mdl-31252614

Subject(s)

Antineoplastic Agents/pharmacology; Thiadiazoles/chemical synthesis; Thiadiazoles/pharmacology; A549 Cells; Antineoplastic Agents/chemistry; Biological Availability; Cell Proliferation/drug effects; Cell Survival/drug effects; Delayed-Action Preparations; Drug Design; Drug Screening Assays, Antitumor; Humans; Hydrophobic and Hydrophilic Interactions; MCF-7 Cells; Microspheres; Molecular Structure; Solubility; Solvents; Structure-Activity Relationship; Thiadiazoles/chemistry

Key words

1,2,3-triazoles; 1,3,4-thiadiazoles; anticancer activity; drug delivery; green chemistry; microspheres

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thiadiazoles / Antineoplastic Agents Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2019 Type: Article Affiliation country: Egypt

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