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Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties.
Carbajo-Gordillo, Ana I; Rodríguez-Lavado, Julio; Jiménez Blanco, José Luis; Benito, Juan M; Di Giorgio, Christophe; Vélaz, Itziar; Tros de Ilarduya, Concepción; Ortiz Mellet, Carmen; García Fernández, José M.
Affiliation
  • Carbajo-Gordillo AI; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Avda. Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain. jogarcia@iiq.csic.es.
  • Rodríguez-Lavado J; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain. mellet@us.es.
  • Jiménez Blanco JL; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain. mellet@us.es.
  • Benito JM; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Avda. Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain. jogarcia@iiq.csic.es.
  • Di Giorgio C; Institut de Chimie Nice, UMR 7272, Université de Nice Sophia Antipolis, CNRS, 28, Avenue de Valrose, F-06108 Nice, France.
  • Vélaz I; Department of Chemistry, Faculty of Sciences, University of Navarra, E-31080, Pamplona, Spain.
  • Tros de Ilarduya C; Department of Pharmaceutical Technology and Chemistry, School of Pharmacy and Nutrition, University of Navarra, 31080 Pamplona, Spain. ctros@unav.es.
  • Ortiz Mellet C; Department of Organic Chemistry, Faculty of Chemistry, University of Seville, C/Profesor García González 1, 41012 Seville, Spain. mellet@us.es.
  • García Fernández JM; Instituto de Investigaciones Químicas (IIQ), CSIC - Universidad de Sevilla, Avda. Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, Spain. jogarcia@iiq.csic.es.
Chem Commun (Camb) ; 55(57): 8227-8230, 2019 Jul 11.
Article in En | MEDLINE | ID: mdl-31268107
ABSTRACT
An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Surface-Active Agents / Trehalose / Transfection / Nanostructures Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: Spain
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmids / Surface-Active Agents / Trehalose / Transfection / Nanostructures Limits: Animals / Humans Language: En Journal: Chem Commun (Camb) Journal subject: QUIMICA Year: 2019 Type: Article Affiliation country: Spain