Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an <i>rd3</i> mouse model of congenital human blindness.

Dizhoor, Alexander M; Olshevskaya, Elena V; Peshenko, Igor V

Retinal guanylyl cyclase activation by calcium sensor proteins mediates photoreceptor degeneration in an rd3 mouse model of congenital human blindness.

Dizhoor, Alexander M; Olshevskaya, Elena V; Peshenko, Igor V.

Affiliation

Dizhoor AM; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027 adizhoor@salus.edu.
Olshevskaya EV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027.
Peshenko IV; Pennsylvania College of Optometry, Salus University, Elkins Park, Pennsylvania 19027.

J Biol Chem ; 294(37): 13729-13739, 2019 09 13.

Article in En | MEDLINE | ID: mdl-31346032

Subject(s)

Guanylate Cyclase/metabolism; Nuclear Proteins/metabolism; Receptors, Calcium-Sensing/metabolism; Amino Acid Substitution; Animals; Blindness/genetics; Calcium/metabolism; Disease Models, Animal; Eye Abnormalities/genetics; Female; Guanylate Cyclase/physiology; Guanylate Cyclase-Activating Proteins/metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation, Missense; Nuclear Proteins/physiology; Photoreceptor Cells, Vertebrate/metabolism; Photoreceptor Cells, Vertebrate/physiology; Protein Binding/genetics; Receptors, Cell Surface/metabolism; Retina/metabolism; Retinal Degeneration/genetics; Retinal Rod Photoreceptor Cells/metabolism

Key words

GCAP; RD3; RetGC; calcium-binding protein; eye; guanylate cyclase (guanylyl cyclase); phototransduction; retinal degeneration; vision

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Proteins / Receptors, Calcium-Sensing / Guanylate Cyclase Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: J Biol Chem Year: 2019 Type: Article

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