Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress.

Du, Yao; Han, Jibo; Zhang, Haixia; Xu, Jianjiang; Jiang, Liqin; Ge, Weihong

Du, Yao; Han, Jibo; Zhang, Haixia; Xu, Jianjiang; Jiang, Liqin; Ge, Weihong.

Affiliation

Du Y; Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Han J; Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Zhang H; Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Xu J; Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Jiang L; Department of Cardiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang, China.
Ge W; Department of Pharmacy, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.

J Cardiovasc Pharmacol ; 74(4): 326-335, 2019 10.

Article in En | MEDLINE | ID: mdl-31356553

Subject(s)

Angiotensin II; Anti-Inflammatory Agents/pharmacology; Antioxidants/pharmacology; Heart Failure/drug therapy; Inflammation Mediators/metabolism; Kaempferols/pharmacology; Myocytes, Cardiac/drug effects; Oxidative Stress/drug effects; Ventricular Function, Left/drug effects; Ventricular Remodeling/drug effects; AMP-Activated Protein Kinases/metabolism; Animals; Cells, Cultured; Collagen/metabolism; Disease Models, Animal; Fibroblasts/drug effects; Fibroblasts/metabolism; Fibroblasts/pathology; Fibrosis; Heart Failure/chemically induced; Heart Failure/metabolism; Heart Failure/physiopathology; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases/metabolism; Myocytes, Cardiac/metabolism; Myocytes, Cardiac/pathology; NF-E2-Related Factor 2/metabolism; NF-kappa B/metabolism; Rats, Sprague-Dawley; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Angiotensin II / Ventricular Function, Left / Oxidative Stress / Inflammation Mediators / Ventricular Remodeling / Myocytes, Cardiac / Kaempferols / Heart Failure / Anti-Inflammatory Agents / Antioxidants Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cardiovasc Pharmacol Year: 2019 Type: Article Affiliation country: China

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