Amyloid-ß induced neuropathological actions are suppressed by Padina gymnospora (Phaeophyceae) and its active constituent &#945;-bisabolol in Neuro2a cells and transgenic Caenorhabditis elegans Alzheimer's model.

Shanmuganathan, Balakrishnan; Sathya, Sethuraman; Balasubramaniam, Boopathi; Balamurugan, Krishnaswamy; Devi, Kasi Pandima

Amyloid-ß induced neuropathological actions are suppressed by Padina gymnospora (Phaeophyceae) and its active constituent α-bisabolol in Neuro2a cells and transgenic Caenorhabditis elegans Alzheimer's model.

Shanmuganathan, Balakrishnan; Sathya, Sethuraman; Balasubramaniam, Boopathi; Balamurugan, Krishnaswamy; Devi, Kasi Pandima.

Affiliation

Shanmuganathan B; Department of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Sathya S; Department of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Balasubramaniam B; Department of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Balamurugan K; Department of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India.
Devi KP; Department of Biotechnology, Alagappa University, Karaikudi, 630003, Tamil Nadu, India. Electronic address: devikasi@yahoo.com.

Nitric Oxide ; 91: 52-66, 2019 10 01.

Article in En | MEDLINE | ID: mdl-31362072

Subject(s)

Alzheimer Disease/drug therapy; Amyloid beta-Peptides/metabolism; Biological Products/pharmacology; Monocyclic Sesquiterpenes/pharmacology; Neuroprotective Agents/pharmacology; Peptide Fragments/metabolism; Phaeophyceae/chemistry; Alzheimer Disease/chemically induced; Amyloid beta-Peptides/genetics; Animals; Animals, Genetically Modified; Apoptosis/drug effects; Caenorhabditis elegans/genetics; Cell Line, Tumor; Enzyme Inhibitors/pharmacology; Humans; Membrane Potential, Mitochondrial/drug effects; Mice; Oxidative Stress/drug effects; Peptide Fragments/genetics; Reactive Nitrogen Species/metabolism; Reactive Oxygen Species/metabolism

Key words

Alzheimer's disease; Aß(2535) peptide; Neuro2a cells; Transgenic Caenorhabditis elegans; α-bisabolol

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptide Fragments / Biological Products / Amyloid beta-Peptides / Neuroprotective Agents / Phaeophyceae / Alzheimer Disease / Monocyclic Sesquiterpenes Limits: Animals / Humans Language: En Journal: Nitric Oxide Journal subject: BIOQUIMICA / QUIMICA Year: 2019 Type: Article Affiliation country: India

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