Curcumin mitigates the epithelial-to-mesenchymal transition in biliary epithelial cells through upregulating CD109 expression.

Fan, Junyu; Wang, Qian; Zhang, Zhuoya; Sun, Lingyun

Fan, Junyu; Wang, Qian; Zhang, Zhuoya; Sun, Lingyun.

Affiliation

Fan J; Department of Integrated Traditional Chinese and Western Medicine, Huashan Hospital Affiliated to Fudan University, Shanghai, China.
Wang Q; Department of Rheumatology and Immunology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
Zhang Z; Department of Rheumatology and Immunology, Drum Tower Hospital Affiliated to Nanjing University, Nanjing, China.
Sun L; Department of Rheumatology and Immunology, Drum Tower Hospital Affiliated to Nanjing University, Nanjing, China.

Drug Dev Res ; 80(7): 992-999, 2019 11.

Article in En | MEDLINE | ID: mdl-31403228

Subject(s)

Antigens, CD/biosynthesis; Curcumin/pharmacology; Epithelial Cells/drug effects; Epithelial-Mesenchymal Transition/drug effects; Neoplasm Proteins/biosynthesis; Up-Regulation/drug effects; Animals; Cell Proliferation/drug effects; Cells, Cultured; Epithelial Cells/metabolism; Female; GPI-Linked Proteins/biosynthesis; Hedgehog Proteins/metabolism; Humans; Mice; Smad2 Protein/biosynthesis; Smad3 Protein/biosynthesis; Smad7 Protein/biosynthesis; Transforming Growth Factor beta1/antagonists & inhibitors; Transforming Growth Factor beta1/pharmacology

Key words

CD109; TGF-ß1; curcumin; epithelial-to-mesenchymal transition; primary biliary cholangitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antigens, CD / Up-Regulation / Curcumin / Epithelial Cells / Epithelial-Mesenchymal Transition / Neoplasm Proteins Limits: Animals / Female / Humans Language: En Journal: Drug Dev Res Year: 2019 Type: Article Affiliation country: China

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