Interplay between Intrinsic and Innate Immunity during HIV Infection.
Cells
; 8(8)2019 08 17.
Article
in En
| MEDLINE
| ID: mdl-31426525
ABSTRACT
Restriction factors are antiviral components of intrinsic immunity which constitute a first line of defense by blocking different steps of the human immunodeficiency virus (HIV) replication cycle. In immune cells, HIV infection is also sensed by several pattern recognition receptors (PRRs), leading to type I interferon (IFN-I) and inflammatory cytokines production that upregulate antiviral interferon-stimulated genes (ISGs). Several studies suggest a link between these two types of immunity. Indeed, restriction factors, that are generally interferon-inducible, are able to modulate immune responses. This review highlights recent knowledge of the interplay between restriction factors and immunity inducing antiviral defenses. Counteraction of this intrinsic and innate immunity by HIV viral proteins will also be discussed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Interferon Type I
/
HIV Infections
/
HIV-1
/
Interferon Regulatory Factors
/
Receptors, Pattern Recognition
/
Host Microbial Interactions
Limits:
Animals
/
Humans
Language:
En
Journal:
Cells
Year:
2019
Type:
Article
Affiliation country:
France