Liraglutide improves hepatic steatosis and metabolic dysfunctions in a 3-week dietary mouse model of nonalcoholic steatohepatitis.

Duparc, Thibaut; Briand, François; Trenteseaux, Charlotte; Merian, Jules; Combes, Guillaume; Najib, Souad; Sulpice, Thierry; Martinez, Laurent O

Duparc, Thibaut; Briand, François; Trenteseaux, Charlotte; Merian, Jules; Combes, Guillaume; Najib, Souad; Sulpice, Thierry; Martinez, Laurent O.

Affiliation

Duparc T; INSERM, Université de Toulouse, UMR1048, Institute of Metabolic and Cardiovascular Diseases (I2MC), Toulouse, France.
Briand F; Physiogenex SAS, Prologue Biotech, Labège-Innopole, France.
Trenteseaux C; Lifesearch SAS, Toulouse, France.
Merian J; INSERM, Université de Toulouse, UMR1048, Institute of Metabolic and Cardiovascular Diseases (I2MC), Toulouse, France.
Combes G; INSERM, Université de Toulouse, UMR1048, Institute of Metabolic and Cardiovascular Diseases (I2MC), Toulouse, France.
Najib S; INSERM, Université de Toulouse, UMR1048, Institute of Metabolic and Cardiovascular Diseases (I2MC), Toulouse, France.
Sulpice T; Physiogenex SAS, Prologue Biotech, Labège-Innopole, France.
Martinez LO; INSERM, Université de Toulouse, UMR1048, Institute of Metabolic and Cardiovascular Diseases (I2MC), Toulouse, France.

Am J Physiol Gastrointest Liver Physiol ; 317(4): G508-G517, 2019 10 01.

Article in En | MEDLINE | ID: mdl-31460789

Subject(s)

Hypoglycemic Agents/pharmacology; Liraglutide/pharmacology; Non-alcoholic Fatty Liver Disease/drug therapy; Non-alcoholic Fatty Liver Disease/metabolism; 2-Hydroxypropyl-beta-cyclodextrin; Animals; Cholesterol, Dietary; Cholic Acid/metabolism; Diet; Diet, High-Fat; Insulin Resistance; Lipid Metabolism/drug effects; Liver/pathology; Liver Cirrhosis/pathology; Metabolic Diseases/drug therapy; Metabolic Diseases/etiology; Metabolic Diseases/metabolism; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease/pathology

Key words

dietary model; drug development; dyslipidemia; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Non-alcoholic Fatty Liver Disease / Liraglutide / Hypoglycemic Agents Type of study: Etiology_studies Limits: Animals Language: En Journal: Am J Physiol Gastrointest Liver Physiol Journal subject: FISIOLOGIA / GASTROENTEROLOGIA Year: 2019 Type: Article Affiliation country: France

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