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High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.
Hiemstra, Steven; Ramaiahgari, Sreenivasa C; Wink, Steven; Callegaro, Giulia; Coonen, Maarten; Meerman, John; Jennen, Danyel; van den Nieuwendijk, Karen; Dankers, Anita; Snoeys, Jan; de Bont, Hans; Price, Leo; van de Water, Bob.
Affiliation
  • Hiemstra S; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • Ramaiahgari SC; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • Wink S; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
  • Callegaro G; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • Coonen M; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • Meerman J; Department of Toxicogenomics, GROW School of Oncology and Development Biology, Maastricht University, Maastricht, The Netherlands.
  • Jennen D; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • van den Nieuwendijk K; Department of Toxicogenomics, GROW School of Oncology and Development Biology, Maastricht University, Maastricht, The Netherlands.
  • Dankers A; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • Snoeys J; Department of Pharmacokinetics, Dynamics and Metabolism, Janssen Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium.
  • de Bont H; Department of Pharmacokinetics, Dynamics and Metabolism, Janssen Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium.
  • Price L; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
  • van de Water B; Division of Drug Discovery and Safety, Leiden Academic Centre for Drug Research (LACDR), Leiden University, Leiden, The Netherlands.
Arch Toxicol ; 93(10): 2895-2911, 2019 10.
Article in En | MEDLINE | ID: mdl-31552476
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spheroids, Cellular / Hepatocytes / Chemical and Drug Induced Liver Injury Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Arch Toxicol Year: 2019 Type: Article Affiliation country: Netherlands
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spheroids, Cellular / Hepatocytes / Chemical and Drug Induced Liver Injury Type of study: Diagnostic_studies / Etiology_studies / Prognostic_studies Limits: Humans Language: En Journal: Arch Toxicol Year: 2019 Type: Article Affiliation country: Netherlands