Comparison of Gene Expression Responses in the Small Intestine of Mice Following Exposure to 3 Carcinogens Using the S1500+ Gene Set Informs a Potential Common Adverse Outcome Pathway.

Chappell, Grace A; Rager, Julia E; Wolf, Jeffrey; Babic, Milos; LeBlanc, Kyle J; Ring, Caroline L; Harris, Mark A; Thompson, Chad M

Chappell, Grace A; Rager, Julia E; Wolf, Jeffrey; Babic, Milos; LeBlanc, Kyle J; Ring, Caroline L; Harris, Mark A; Thompson, Chad M.

Affiliation

Chappell GA; ToxStrategies, Inc, Asheville, NC, USA.
Rager JE; ToxStrategies, Inc, Austin, TX, USA.
Wolf J; Experimental Pathology Laboratories, Sterling, VA, USA.
Babic M; BioSpyder Technologies, Inc., Carlsbad, CA, USA.
LeBlanc KJ; BioSpyder Technologies, Inc., Carlsbad, CA, USA.
Ring CL; ToxStrategies, Inc, Asheville, NC, USA.
Harris MA; ToxStrategies, Inc., Katy, TX, USA.
Thompson CM; ToxStrategies, Inc., Katy, TX, USA.

Toxicol Pathol ; 47(7): 851-864, 2019 10.

Article in En | MEDLINE | ID: mdl-31558096

Subject(s)

Captan/toxicity; Carcinogens/toxicity; Chromium/toxicity; Intestine, Small/drug effects; Phthalimides/toxicity; Animals; Gene Expression Profiling; Hypoxia-Inducible Factor 1, alpha Subunit/physiology; Intestine, Small/metabolism; Intestine, Small/pathology; Mice

Key words

S1500+; adverse outcome pathway; captan; folpet; hexavalent chromium; intestinal cancer; mechanism of action; mode of action; rodent pathology; transcriptomics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phthalimides / Captan / Carcinogens / Chromium / Intestine, Small Type of study: Prognostic_studies Limits: Animals Language: En Journal: Toxicol Pathol Year: 2019 Type: Article Affiliation country: United States

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