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A novel UHPLC-HRMS-based metabolomics strategy enables the discovery of potential neuroactive metabolites in mice plasma, following i.p. administration of the main Crocus sativus L. bioactive component.
Karkoula, Evangelia; Dagla, Ioanna-Valentini; Baira, Eirini; Kokras, Nikolaos; Dalla, Christina; Skaltsounis, Alexios-Leandros; Gikas, Evagelos; Tsarbopoulos, Anthony.
Affiliation
  • Karkoula E; Medical School, National and Kapodistrian University of Athens, Department of Pharmacology, 115 27 Athens, Greece; GAIA Research Center, The Goulandris Natural History Museum, Bioanalytical Department, 145 62 Kifissia, Greece.
  • Dagla IV; Department of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.
  • Baira E; Department of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.
  • Kokras N; Medical School, National and Kapodistrian University of Athens, Department of Pharmacology, 115 27 Athens, Greece; First Department of Psychiatry, Eginition Hospital, Medical School, National and Kapodistrian University of Athens, 115 27 Athens, Greece.
  • Dalla C; Medical School, National and Kapodistrian University of Athens, Department of Pharmacology, 115 27 Athens, Greece.
  • Skaltsounis AL; Department of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.
  • Gikas E; Department of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece.
  • Tsarbopoulos A; Medical School, National and Kapodistrian University of Athens, Department of Pharmacology, 115 27 Athens, Greece; GAIA Research Center, The Goulandris Natural History Museum, Bioanalytical Department, 145 62 Kifissia, Greece. Electronic address: atsarbop@med.uoa.gr.
J Pharm Biomed Anal ; 177: 112878, 2020 Jan 05.
Article in En | MEDLINE | ID: mdl-31561062
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carotenoids / Neuroprotective Agents / Crocus / Metabolomics Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharm Biomed Anal Year: 2020 Type: Article Affiliation country: Greece
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Carotenoids / Neuroprotective Agents / Crocus / Metabolomics Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharm Biomed Anal Year: 2020 Type: Article Affiliation country: Greece