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Application of Three-dimensional (3D) Tumor Cell Culture Systems and Mechanism of Drug Resistance.
Shehzad, Adeeb; Ravinayagam, Vijaya; AlRumaih, Hamad; Aljafary, Meneerah; Almohazey, Dana; Almofty, Sarah; Al-Rashid, Noor A; Al-Suhaimi, Ebtesam A.
Affiliation
  • Shehzad A; Department of Clinical Pharmacy, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Ravinayagam V; Scientific Research & Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • AlRumaih H; College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Aljafary M; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Almohazey D; Stem Cell Research Department, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Almofty S; Stem Cell Research Department, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Al-Rashid NA; Department of Clinical Pharmacy, Institute for Research and Medical Consultations, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
  • Al-Suhaimi EA; Department of Biology, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Curr Pharm Des ; 25(34): 3599-3607, 2019.
Article in En | MEDLINE | ID: mdl-31612821
ABSTRACT
The in-vitro experimental model for the development of cancer therapeutics has always been challenging. Recently, the scientific revolution has improved cell culturing techniques by applying three dimensional (3D) culture system, which provides a similar physiologically relevant in-vivo model for studying various diseases including cancer. In particular, cancer cells exhibiting in-vivo behavior in a model of 3D cell culture is a more accurate cell culture model to test the effectiveness of anticancer drugs or characterization of cancer cells in comparison with two dimensional (2D) monolayer. This study underpins various factors that cause resistance to anticancer drugs in forms of spheroids in 3D in-vitro cell culture and also outlines key challenges and possible solutions for the future development of these systems.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spheroids, Cellular / Drug Resistance, Neoplasm / Cell Culture Techniques / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Curr Pharm Des Journal subject: FARMACIA Year: 2019 Type: Article Affiliation country: Saudi Arabia
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spheroids, Cellular / Drug Resistance, Neoplasm / Cell Culture Techniques / Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Curr Pharm Des Journal subject: FARMACIA Year: 2019 Type: Article Affiliation country: Saudi Arabia